The seashore is a 56 mile long section of the Outer Banks of North Carolina running from Ocracoke Inlet on the northeast to Beaufort Inlet on the southeast. The three undeveloped barrier islands which make up the seashore, North Core Banks, South Core Banks and Shackleford Banks, protect one of the few remaining natural coastal barrier island systems in the world. Its native grasslands comprise the only remaining natural grasslands in the eastern United States. Small populations of the endangered sea beach amaranth grow within the national seashore. Here, also, marks the northernmost edge of the range of the Loggerhead Turtle, a marine turtle on the Federal List of Threatened and Endangered Species. The national seashore also provides one of the southernmost habitats for the federally listed piping plover. Other endangered species that visit Cape Lookout National Seashore include Roseate Terns, Peregrine Falcons, and Bald Eagles. Also, more than 100 wild horses roam Shackleford Banks island.

Stretched over 70 miles of barrier islands, Cape Hatteras National Seashore is a fascinating combination of natural and cultural resources, and provides a wide variety of recreational opportunities. Once dubbed the "Graveyard of the Atlantic" for its treacherous currents, shoals, and storms, Cape Hatteras has a wealth of history relating to shipwrecks, lighthouses, and the U.S. Lifesaving Service. These dynamic islands provide a variety of habitats and are a valuable wintering area for migrating waterfowl. The park's fishing and surfing are considered the best on the east coast.

Ridge upon ridge of endless forest straddling the border between North Carolina and Tennessee, Great Smoky Mountains National Park is one of the largest protected areas in the Eastern United States. World renowned for the diversity of its plant and animal life, the beauty of its ancient mountains, the quality of its remnants of Southern Appalachian mountain culture, and the depth and integrity of its wilderness sanctuary, the park attracts over nine million visitors each year. Once a part of the Cherokee homeland, the Smokies today are a hiker's paradise with over 800 miles of trails.

The Appalachian National Scenic Trail is a 2,180-mile footpath along the ridgecrests and across the major valleys of the Appalachian Mountains from Katahdin in Maine to Springer Mountain in northern Georgia. It traverses the scenic, wooded, pastoral, wild, and culturally resonant lands of the Appalachian Mountains. Conceived in 1921, it was built by private citizens and completed in 1937. The trail traverses Maine, New Hampshire, Vermont, Massachusetts, Connecticut, New York, New Jersey, Pennsylvania, Maryland, West Virginia, Virginia, Tennessee, North Carolina and Georgia.